Fig 4. Alcohol is associated with reduced OPSCC survival time.

(A-D) Prognostic outcomes of the alcohol, smoking, and betel quid variables within the whole cohort. We analyzed up to 5-year overall survival (OS) and disease-free survival (DFS) outcomes for high-risk habits. (A) Table includes the multivariable hazard probabilities analyzed using Cox survival models and hazard ratio (HR) estimations, visualized by forest plots, where estimates were reported for full model with all covariates (HPV status, alcohol, smoking, betel quid, age, N- and T-stage) included as fixed effects. The complete analysis is found in S6 Table. (B-D) Kaplan-Meier survival analysis. Plots represent the results for up to 5-year OS (left) and DFS (right) comparison between alcohol (B), smoke (C), and betel quid (D) groups. Log-rank analysis was used to compare the survival distributions (log-rank p-values are in the plots).