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. 2021 Apr 23;16(4):e0250530. doi: 10.1371/journal.pone.0250530

Fig 5. In alcohol users, HPV is associated with improved OPSCC survival time.

Fig 5

(A-C) Prognostic outcomes of the alcohol, smoking, and betel quid variables within HPV risk groups. HPV positivity is defined as HPV DNA-positive and/or p16-positive. We analyzed up to 5-year overall survival (OS) and disease-free survival (DFS) outcomes. (A) Table includes the multivariable hazard probabilities analyzed using Cox survival models and hazard ratio (HR) estimations, adjusted for age, T- and N-stage, and visualized by forest plots. (B-C) Kaplan-Meier survival analysis. Plots represent the results for up to 5-year OS (B) and DFS (C) comparison between HPV groups stratified by alcohol groups. Log-rank analysis was used to compare the survival distributions (log-rank p-values are in the plots). The complete analysis is found in S7 Table and S3 Fig. HPV-, HPV-negative; HPV+, HPV-positive.