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. 2021 Apr 23;16(4):e0250046. doi: 10.1371/journal.pone.0250046

Table 5. Classification of endometriosis and specific comments about the surgery performed in the 22 women who were not considered responders for deep dyspareunia.

Case Phenotype ENZIAN rASRM Additional information
Nonresponder
1 P B1 2
2 D B3FA 2 Hysteroscopy and cholecystectomy also performed.
3 P+D A2B3C1 3 Adenomyosis on MRI.
4 D A1B1 1
5 E+P+D B3C1FAFI 3 Endometriosis in appendix and cecum.
6 P+D A3B3FB3 4 Excision of nodule involving sacral roots. Protective ileostomy. Postoperative vault hematoma. Adenomyosis on MRI.
7 D A2B3FA 3
8 P+D A1B3FA 2
9 D B1 1 Robotic assisted.
10 P+D A1B1C2 2 Adenomyosis on MRI.
11 D B1 1 Adenomyosis on MRI.
12 D A1B3 1 Nodule involving lower right hypogastric plexus, almost reaching sacral roots.
Paradoxical
13 D A3 NA Previous vaginal hysterectomy. Major adherence involving rectum and left ovary.
14 D B1FA 2
15 D A3C1FA 4
“de novo”
16 D B1 1 Adenomyosis on MRI.
17 E+P+D A2B2FI 4 Endometriosis apendicular. Fitz-Hugh-Curtis syndrome.
18 D B3FA 3 Permanent ligation of the uterine arteries and ascending branch of the right uterine artery.
19 D B2 NA Robotic assisted. Previous hysterectomy (adnexa preserved bilaterally).
20 P+D A1B3 2 Postoperative infected vault hematoma. Adenomyosis on MRI.
21 E+P+D A3B3C3FAFI 4 Robotic assisted. Cholecystectomy also performed.
22 P+D A3B3FA 4 Robotic assisted.

Nonresponders: NRS changed by less than 3 points. Paradoxical response: NRS ↑ by 3 points or more. “de novo” dyspareunia: NRS prior to surgery = 0 and NRS ↑ by 3 points or more. Phenotype: P peritoneal endometriosis; E endometrioma; D lesions deeper than 5 mm. ENZIAN: Revised classification (2012). rASRM: Revised American Society of Reproductive Medicine staging classification (1996). Adenomyosis on MRI: Adenomyosis was reported by a radiologist who reviewed the Magnetic Resonance Imaging, but was not surgically explored and thus not included in ENZIAN classification.