Table 2.

Standard Risk B-ALL Regimen (Adapted from Children’s Oncology Group AALL0932)

Phase	Chemotherapy Agents	Schedule
Induction (35 days)	Dexamethasone PO	Days 1–28
	Vincristine IV	Days 1, 8, 15, 22
	Pegaspargase IV	Day 4
	Cytarabine IT	Day 1 (CNS2 require more)
	Methotrexate IT	Days 8, 29
Consolidation (28 days)	Mercaptopurine PO	Days 1–28
	Vincristine IV	Day 1
	Methotrexate IT	Days 1, 8, 15
Interim Maintenance (IM 1) (56 days)	Vincristine IV	Days 1, 11, 21, 31, 41
	Methotrexate IV (escalating dose)	Days 1, 11, 21, 31, 41
	Methotrexate IT	Day 31
Delayed Intensification (56 days)	Dexamethasone PO	Days 1–7 and 15–21
	Thioguanine PO	Days 29–42
	Vincristine IV	Days 1, 8, 15
	Doxorubicin IV	Days 1, 8, 15
	Pegaspargase IV	Day 4
	Cyclophosphamide IV	Day 29
	Cytarabine IV	Days 29–32 and 36–39
	Methotrexate IT	Days 1, 29
Interim Maintenance (IM 2) (56 days)	Vincristine IV	Days 1, 11, 21, 31, 41
	Methotrexate IV (escalating dose)	Days 1, 11, 21, 31, 41
	Methotrexate IT	Days 1, 31
Maintenance (12-week cycles for 2 years from IM 1)	Dexamethasone PO	Days 1–5, 29–33, and 57–61
	Mercaptopurine PO	Days 1–84
	Methotrexate PO	Weekly starting Day 8
	Vincristine IV	Days 1, 29, 57
	Methotrexate IT	Day 1

Abbreviations: PO, oral; IV, intravenous; IT, intrathecal; CNS, central nervous system.