Table 4.

Relapse ALL Regimen (Adapted from UKALLR3)

Phase	Chemotherapy Agents	Schedule
Induction (28 days)	Dexamethasone PO	Days 1–5, 15–19
	Vincristine IV	Days 3, 10, 17, 24
	Mitoxantrone IV	Days 1, 2
	Pegaspargase IM/IV	Days 3, 18
	Methotrexate IT	Days 1, 8 (also Days 15, 22 for CNS3)
Consolidation (28 days)	Dexamethasone PO	Days 1–5
	Vincristine IV	Day 3
	Methotrexate IV	Day 8
	Pegaspargase IM/IV	Day 9
	Cyclophosphamide IV	Days 15–19
	Etoposide IV	Days 15–19
	Methotrexate IT	Day 8
Intensification (28 days)	Dexamethasone PO	Days 1–5
	Vincristine IV	Day 3
	Cytarabine IV, every 12 hours	Days 1, 2, 8, 9
	Erwinia ASP IM	Days 2, 4, 9, 11, 23
	Methotrexate IV	Day 22
	Methotrexate IT	Days 1, 22
Before SCT	Fludarabine IV	Days 1–5
	Cytarabine IV	Days 1–5
	Liposomal Daunorubicin IV	Day 1
Before Maintenancea (weeks 14–29)	Dexamethasone PO	Days 1–5, 57–61
	Vincristine IV	Days 3, 59
	6-mercaptopurine PO	Days 1–42, 57–98
	Methotrexate PO	Days 10, 17, 31, 38, 67, 74, 88, 95
	Etoposide IV	Days 42, 49, 99, 106
	Cyclophosphamide IV	Days 42, 49, 99, 106
	Cytarabine IV	Days 43–46, 50–53, 100–103, 107–110
	Methotrexate IT	Days 1, 43, 57, 99
Maintenancea (4-week cycles from weeks 30–104)	Dexamethasone PO	Days 1–5
	Mercaptopurine PO	Days 1–28
	Methotrexate PO	Weekly
	Vincristine IV	Day 1
	Methotrexate IT	Day 1

Note: ^aPhase given to patients who did not go to SCT.

Abbreviations: PO, oral; IV, intravenous; IM, intramuscular; IT, intrathecal; CNS, central nervous system; SCT, stem cell transplant; ASP, asparaginase.