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. 2021 Apr 19;14:1551–1561. doi: 10.2147/JIR.S302967

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© 2021 Zhou et al.

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TLR4 deletion accelerates lung injury and the local inflammatory response induced by the HMGB1 instillation. (A) Pathological changes in lung tissues from TLR4 mice with different genotypes 48 h after an intratracheal instillation of HMGB1. (B) The morphological changes was quantified by using lung injury scoring system (C) Changes in the W/D weight ratio of the lung tissue 48 h after an intratracheal instillation of HMGB1 in mice with different TLR4 genotypes. (D) TNF-α levels were measured in BAL fluid from the control, WT, and TLR4^-/- groups using an ELISA. (E) Serum TNF-α was measured by ELISA in the control, WT, and TLR4^-/- groups. (F) IL-1β levels were measured in BAL fluid from the control, WT, and TLR4^-/- groups using an ELISA. (G) Serum IL-1β levels were measured in the control, WT, and TLR4^-/- groups using an ELISA, *p<0.05 between 3 groups by using Tukey’s test, ^&p<0.05 between WT and TLR4^-/- group by using t-test.