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. 2021 Apr 9;15:644100. doi: 10.3389/fnins.2021.644100

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Copyright © 2021 Acutain, Griebler Luft, Vazquez, Popik, Cercato, Epstein, Salvetti, Jerusalinsky, de Oliveira Alvares and Baez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fear conditioning. (A) Representative scheme of the experimental design. Habituation to the context for 10 min on 2 consecutive days. Then, in the conditioning session, the tone (CS) was paired with 0.5-mA foot shock. Tone test: exposure to the tone in a novel context. Context test: exposure to the conditioning context. (B) shGluN2A-injected animals showed similar freezing behavior during the conditioning session compared to shsc-injected rats (p = 0.6722, unpaired t test). (C) There was no difference in freezing behavior between control and shGLUN2A-injected animals in the tone test (p = 0.8537, unpaired t test). (D) shGLUN2A-injected rats showed a significant decrease in freezing expression during the context test (*p < 0.05, unpaired t test). Data are represented as mean ± SEM. N = 9 shsc-injected, N = 11 shGLUN2A-injected animals.