TABLE 1.
Baseline Characteristics According to Quartile of Cholesterol Measures of Atherogenic Dyslipidemia Complex in the Reference Subcohort
| Cholesterol Measure | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
|---|---|---|---|---|---|---|
| Number of subjects | TRL cholesterol† | n | 120 | 129 | 122 | 125 |
| nW | 7,384 | 6,815 | 6,765 | 6,354 | ||
| Small dense LDL cholesterol | n | 120 | 133 | 120 | 123 | |
| nW | 7,428 | 7,684 | 6,056 | 6,150 | ||
| Age, yrs | TRL cholesterol | 50.1 (1.00) | 53.2 (1.28) | 51.6 (1.09) | 54.4 (1.17) | |
| Small dense LDL cholesterol | 49.1 (0.94) | 51.8 (1.24) | 53.1 (1.04) | 55.2 (1.22) | ||
| Body mass index, kg/m2 | TRL cholesterol | 22.5 (0.56) | 24.6 (0.55) | 25.6 (0.58) | 26.6 (0.69) | |
| Small dense LDL cholesterol | 22.6 (0.54) | 25.5 (0.57) | 24.8 (0.59) | 26.4 (0.59) | ||
| History of diabetes mellitus | TRL cholesterol | 1.3 | 1.4 | 1.3 | 9.6 | |
| Small dense LDL cholesterol | 0.0 | 1.1 | 4.6 | 7.2 | ||
| History of hypertension | TRL cholesterol | 30.3 | 37.3 | 36.6 | 48.3 | |
| Small dense LDL cholesterol | 26.2 | 33.6 | 37.6 | 50.8 | ||
| Current smoker | TRL cholesterol | 9.0 | 11.4 | 10.1 | 14.9 | |
| Small dense LDL cholesterol | 9.10 | 9.50 | 12.60 | 14.70 | ||
| Parental history of myocardial infarction | TRL cholesterol | 11.4 | 14.6 | 20.1 | 21.9 | |
| Small dense LDL cholesterol | 13.7 | 14.0 | 79.7 | 21.9 | ||
| Alcohol, ≥1 serving/week | TRL cholesterol | 51.8 | 49.8 | 36.3 | 37.7 | |
| Small dense LDL cholesterol | 47.1 | 49.4 | 39.0 | 39.7 | ||
| Exercise, ≥1 episode/week | TRL cholesterol | 43.8 | 36.3 | 37.2 | 39.6 | |
| Small dense LDL cholesterol | 46.0 | 35.8 | 39.4 | 36.6 | ||
| Menopausal hormone therapy | TRL cholesterol | 38.0 | 53.3 | 41.5 | 47.2 | |
| Small dense LDL cholesterol | 29.8 | 49.1 | 45.6 | 53.6 | ||
| Total cholesterol, mg/dl | TRL cholesterol | 191.0 (4.2) | 213.3 (5.3) | 211.0 (5.4) | 240.3 (4.7) | |
| Small dense LDL cholesterol | 181.7 (4.3) | 208.5 (4.1) | 225.3 (5.2) | 245.4 (3.9) | ||
| High-density lipoprotein cholesterol, mg/dl | TRL cholesterol | 58.6 (1.7) | 52.1 (1.7) | 45.2 (2.2) | 41.6 (1.6) | |
| Small dense LDL cholesterol | 56.2 (2.3) | 52.5 (2.1) | 45.9 (2.6) | 43.4 (2.1) | ||
| Low-density lipoprotein cholesterol, mg/dl | TRL cholesterol | 108.1 (4.5) | 125.7 (5.8) | 126.3 (5.3) | 148.4 (5.6) | |
| Small dense LDL cholesterol | 100.9 (3.9) | 118.9 (3.5) | 140.0 (4.3) | 152.5 (4.8) | ||
| Triglycerides, mg/dl | TRL cholesterol | 76.3 (5.5) | 101.7 (5.5) | 139.9 (6.6) | 204.9 (7.5) | |
| Small dense LDL cholesterol | 74.0 (6.7) | 95.0 (6.2) | 134.0 (8.7) | 196.0 (8.2) | ||
| High-sensitivity C-reactive protein, mg/l | TRL cholesterol | 1.57 (0.27) | 2.19 (0.50) | 3.32 (0.55) | 4.01 (0.61) | |
| Small dense LDL cholesterol | 1.37 (0.50) | 1.87 (0.44) | 2.76 (0.55) | 3.93 (0.54) | ||
| Small dense LDL cholesterol, mg/dl | TRL cholesterol | 24.9 (1.8) | 32.5 (1.7) | 38.4 (1.9) | 57.3 (2.2) | |
| TRL cholesterol, mg/dl | Small dense LDL cholesterol | 24.0 (2.5) | 39.0 (2.5) | 50.0 (3.2) | 72.0 (3.3) | |
Values are % or median (SE) adjusted for matching factors and reweighted to the source population using logistic regression and median regression, respectively. TRL-C quartiles: Q1, <28.0 mg/dl; Q2, 28.0–42.9 mg/dl; Q3, 43.0–60.9 mg/dl; Q4, ≥61.0 mg/dl. Small dense LDL cholesterol quartiles: Q1, <27.0 mg/dl; Q2, 27.0–37.9 mg/dl; Q3, 38.0–50.9 mg/dl; Q4, ≥51.0 mg/dl. nw = reweighted number of subjects. Reweighted nw represent the approximate number of subjects expected within each quartile of TRL cholesterol and small dense LDL cholesterol had the entire WHS blood cohort been analyzed.
LDL = low-density lipoprotein; TRL = triglyceride rich lipoprotein.