Figure 5.

47D1 protects Syrian hamsters from SARS-CoV-2 challenge

Syrian hamsters were intraperitoneally injected with 2,000, 500, 125, 31, or 8 μg/animal of 47D1, or 2,000 μg of Den3, followed by challenge intranasally 12 h post-infusion with 1 × 10⁶ PFU of SARS-CoV-2. These animals were then challenged with 1 × 10⁶ PFU of SARS-CoV-2 (USA-WA1/2020) intranasally 12 h after antibody injection. Weight loss over the course was recorded (A) and lung viral loads at day 5 were quantified by qPCR (B). Experiments were performed with five hamsters in each group. Data are represented as mean ± SEM. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, determined using a Student’s t test comparing 47D1-treated groups with the Den3 control group. n.s., not significant (p > 0.05).