Table 1.
Evaluation of disinfectant effectiveness against SARS-CoV-2 and IAV
| Log reduction (SARS-CoV-2) |
Log reduction (IAV) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
in vitro |
on skin |
in vitro |
on skin |
|||||||||
| 5 s | 15 s | 60 s | 5 s | 15 s | 60 s | 5 s | 15 s | 60 s | 5 s | 15 s | 60 s | |
| 80% EA | >4.50 | >4.50 | >4.50 | >4.19 | >4.17 | >4.14 | >4.10 | >4.11 | >4.07 | >4.12 | >4.16 | >4.16 |
| 60% EA | >4.50 | >4.50 | >4.50 | >4.19 | >4.17 | >4.14 | >4.10 | >4.11 | >4.07 | >4.12 | >4.16 | >4.16 |
| 40% EA | >4.50 | >4.50 | >4.50 | >4.19 | >4.17 | >4.14 | >4.10 | >4.11 | >4.07 | >4.12 | >4.16 | >4.16 |
| 20% EA | 0.08 ± 0.14 | 0.25 ± 0.25 | 0.33 ± 0.14 | 0.53 ± 0.23 | 0.61 ± 0.22 | 0.81 ± 0.27 | 0.09 ± 0.07 | 0.07 ± 0.05 | 0.06 ± 0.07 | 0.73 ± 0.08 | 0.85 ± 0.24 | 0.88 ± 0.28 |
| 70% IPA | >4.50 | >4.50 | >4.50 | >4.19 | >4.17 | >4.14 | >4.10 | >4.11 | >4.07 | >4.12 | >4.16 | >4.16 |
| 0.2% CHG | 0.33 ± 0.14 | 0.42 ± 0.14 | 0.58 ± 0.14 | 2.19 ± 0.17 | 2.31 ± 0.21 | 2.42 ± 0.18 | 0.08 ± 0.05 | 0.17 ± 0.04 | 0.19 ± 0.07 | 0.74 ± 0.16 | 0.95 ± 0.14 | 1.02 ± 0.14 |
| 1.0% CHG | 1.00 ± 0.25 | 1.42 ± 0.14 | 1.83 ± 0.29 | 2.64 ± 0.18 | 2.94 ± 0.30 | 3.17 ± 0.33 | 0.23 ± 0.01 | 0.24 ± 0.04 | 0.40 ± 0.06 | 2.85 ± 0.71 | 3.25 ± 0.69 | 3.39 ± 0.55 |
| 0.05% BAC | 1.33 ± 0.52 | 1.75 ± 0.43 | 2.17 ± 0.29 | 2.03 ± 0.51 | 2.19 ± 0.50 | 2.36 ± 0.38 | 0.69 ± 0.13 | 1.78 ± 0.07 | 2.71 ± 0.09 | 0.78 ± 0.20 | 1.04 ± 0.27 | 1.23 ± 0.60 |
| 0.2% BAC | 1.83 ± 0.38 | 2.42 ± 0.58 | 3.00 ± 0.43 | 2.72 ± 0.15 | 2.97 ± 0.20 | 3.19 ± 0.21 | 1.43 ± 0.23 | 2.34 ± 0.04 | >4.07 | 1.64 ± 0.41 | 2.85 ± 0.45 | 3.24 ± 0.81 |
Abbreviations: BAC, benzalkonium chloride; CHG, chlorhexidine gluconate; EA, ethanol; IAV, influenza A virus; IPA, isopropanol; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
The log reduction value was calculated to evaluate disinfectant effectiveness under each condition and was expressed as mean ± standard deviation. Additionally, the log reduction value of the condition wherein the virus was inactivated below the measurement limit was 4 or more and was expressed as ‘>4.xx’.See Fig. 1 for the evaluation results of disinfection effectiveness against SARS-CoV-2 on each human skin sample.