Table 4.
Multivariate Associations of Demographic, Clinical, Symptom and Quality-of-Life Characteristics and Menopausal Palpitation Distress (n = 759)
| Variable | Odds ratio [95% CI] | P |
|---|---|---|
| Smoking (“Never” as reference) | 0.008 | |
| Past | 0.59 [0.38–0.90] | |
| Current | 0.48 [0.27–0.87] | |
| BMI, per 5 kg/m2 | 0.82 [0.69–0.98] | 0.03 |
| Menopausal status (“Postmenopause” as reference) | 0.27 | |
| Perimenopausal | 1.03 [0.65–1.65] | |
| Indeterminate | 0.54 [0.25–1.16] | |
| Vasomotor symptom bother (per one-point) | 1.28 [0.86–1.90] | 0.23 |
| ISI Insomnia (per five-point) | 1.28 [1.05–1.54] | 0.01 |
| PHQ-8 depression (per five-point) | 1.47 [1.11–1.95] | 0.008 |
| PSS stress (per five-point) | 1.19 [1.01–1.39] | 0.03 |
| MENQOL total (per one-point) | 1.29 [1.06–1.57] | 0.01 |
c-statistic = 0.75, model adjusted for MsFLASH trial (1, 2, 3) and clinical center (Philadelphia, Boston, Indianapolis, Oakland, Seattle). Vasomotor severity not included due to high correlation with vasomotor bother. GAD-7 not included due to high correlation with PHQ-8 depression scale.
CI, confidence interval.