Table 2.

Examples of PPII modulators against SARS-CoV/ SARS-CoV-2.

Name	Virus	Type	Mechanism of inhibition	Targets	Ref
SSAA09E2	SARS-CoV	Small molecule	Disturbing S-ACE2 interaction	PPII of S-ACE2 complex	[75]
VE607	SARS-CoV				[76]
Methylene blue	SARS-CoV-2				[77]
Diammonium Glycyrrhizinate	SARS-CoV-2				[78]
corilagin	SARS-CoV-2				[79]
CB6	SARS-CoV-2	Antibody			[80]
B38	SARS-CoV-2				[81]
311mab-31B5 and 311mab-32D4	SARS-CoV-2				[85]
COVA2-15	SARS-CoV-2				[86]
IgG1 ab1	SARS-CoV-2				[87]
hrsACE2	SARS-CoV-2	Soluble peptide analogues of ACE2			[83]
ACE2-Ig	SARS-CoV-2				[88]
EK1C4	SARS-CoV-2	Lipopeptide	Disturbing 6-HB formation of S protein	S protein	[90]
Arbidol	SARS-CoV-2	Small molecule	Modulating S protein trimerization		[96], [127]
S471-503	SARS-CoV	Soluble peptide analogues of S	Disturbing S-ACE2 interaction	host ACE2	[97]
438YKYRYL443	SARS-CoV			host ACE2	[98]
Chloroquine	SARS-CoV-2	Small molecule		atypical PPI inhibition	[105]
Octapeptide	SARS-CoV-2	Peptide-based inhibitor	Disturbing intra-dimer of 3CLpro	3C-like protease	[108], [109]
P3	SARS-CoV-2	Small molecule	Stabilizing a non-native dimer of N-NTD	Nucleocapsid protein	[113]