Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 23;12:2437. doi: 10.1038/s41467-021-22009-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Scatter plots of protein loss and editing efficiency by exon grouping across all base editor approaches employed. The strongest relationship is observed among middle exons, while the weakest is observed in the last exon. Pearson’s correlation coefficient (r) is shown. Error bands represent 95% CI of the mean. b Error in protein loss as a function of editing efficiency across each exon group. Boxplot center lines represent the median, box limits represent the upper and lower quartiles, and whiskers define the 1.5× interquartile range. The least error is observed among middle exons, while the greatest is observed in the last exon. N = 57 unique enzyme-guide combinations with two independent donors. c Scatter plots of the protein loss and editing efficiency grouped by where each BE sgRNA maps to the TCR-CD3 and MHC Class I structures. sgRNAs that map to transmembrane and extracellular regions exhibit the greatest consistency between protein loss and base editing efficiency. Pearson’s correlation coefficient (r) is shown. Error bands represent 95% CI of the mean. Source data are available in the Source Data file.