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. 2021 Apr 23;12:2437. doi: 10.1038/s41467-021-22009-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Conserved genetic elements that can be targeted for gene disruption by base editors. Elements that have been targeted in publications are cited, while additional conserved elements that have not been validated at the time of this publication are indicated as to be determined (TBD). Elements include enhancers⁶⁶, −35 element, −10 element, start codon⁶⁷, Splice donor^15,24, Branch point²⁴, Pyrimidine tract²⁴, Splice acceptor^15,22,24, Nonsense^20,21, Missense⁵⁹, Stop codon, pA signal, pA site. Source data are available in the Source Data file.