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. 2021 Apr 23;11:8857. doi: 10.1038/s41598-021-87857-w

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© The Author(s) 2021

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Quantitative histological analysis method. (A) Schematic of the histogram of gradients (HOG) generation for histological ROIs. (B) Left: examples of HOGs corresponding to tiles with high and low histological kurtosis; right: examples of tiles with different values of histological kurtosis and SD.