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. 2021 Apr 23;11:8847. doi: 10.1038/s41598-021-87492-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A: Pathways enrichment analysis of upregulated (a) and downregulated (b) genes, using p-values < 0.05 as threshold. The transcriptomic analysis was performed on uteri of two 6-months old TG mice (belonging to the TG-hLH-R-frt-200 mouse line) and WT mice. Table shows the number and the percentage of genes involved in each pathway, with the relative fold enrichment. For this analysis the Bonferroni correction was applied. (B): Bar-graph of the mRNA fold increase of 8 genes (excluding hLH-R) showing alterations between TG and WT mice in the microarray data. Data are reported as log2 of 2^-DDCt. The Log2 fold change values from microarray data and Log2 fold change values from RQ-PCR data are used to perform Pearson Correlation Test. p = 0.0032 (two-tailed t-test; n = 4, 2 WT vs 2 TG). R square = 0.85 (Pearson correlation coefficient).