Table 4.
Absorbed dose coefficients for [11C]-UCB-J determined from three healthy subjects using OLINDA/EXM 2.1, compared to OLINDA/EXM 1.1
| Target organ | Absorbed dose coefficients (mSv/MBq) | ||||
|---|---|---|---|---|---|
| Adult female | Adult female | Adult male | Average | % Difference | |
| Adrenals | 4.99E−03 | 4.84E−03 | 4.13E−03 | 4.52E−03 ± 0.56 | 55% |
| Brain | 1.93E−02 | 1.56E−02 | 1.13E−02 | 14.38E−02± 4.35 | −6% |
| Breasts | 1.56E−03 | 1.65E−03 | 1.61E−03 ± 0.06 | 10% | |
| Esophagus | 2.63E−03 | 2.62E−03 | 2.36E−03 | 2.49E−03 ± 0.19 | n/a |
| Eyes | 2.93E−03 | 2.73E−03 | 1.87E−03 | 2.35E−03 ± 0.68 | n/a |
| Gallbladder wall | 1.28E−02 | 4.19E−03 | 7.95E−03 | 8.22E−03 ± 0.39 | 9% |
| Left colon | 3.62E−03 | 3.18E−03 | 3.82E−03 | 3.61E−03 ± 0.30 | 14% |
| Small intestine | 2.67E−02 | 1.82E−02 | 2.46E−02 | 23.53E−02 ± 1.52 | 26% |
| Stomach wall | 9.32E−03 | 5.58E−03 | 6.76E−03 | 7.11E−03 ± 0.49 | 8% |
| Right colon | 8.63E−03 | 6.52E−03 | 9.06E−03 | 8.32E−03 ± 1.05 | 8% |
| Rectum | 3.96E−03 | 3.48E−03 | 2.62E−03 | 3.17E−03 ± 0.78 | n/a |
| Heart wall | 5.33E−03 | 4.97E−03 | 5.82E−03 | 5.49E−03 ± 0.47 | 0% |
| Kidneys | 1.60E−02 | 1.68E−02 | 7.33E−03 | 11.87E−02 ± 6.41 | 1% |
| Liver | 1.58E−02 | 1.54E−02 | 1.35E−02 | 14.55E−02 ± 1.49 | 4% |
| Lungs | 4.09E−03 | 3.85E−03 | 3.80E−03 | 3.89E−03 ± 0.12 | −8% |
| Ovaries | 3.33E−03 | 3.02E−03 | 3.18E−03 ± 0.22 | 68% | |
| Pancreas | 4.66E−03 | 4.16E−03 | 3.89E−03 | 4.15E−03 ± 0.37 | 17% |
| Prostate | 2.50E−03 | 2.50 | n/a | ||
| Salivary glands | 2.64E−03 | 2.52E−03 | 2.00E−03 | 2.29E−03 ± 0. 41 | n/a |
| Red marrow | 4.81E−03 | 4.55E−03 | 3.67E−03 | 4.18E−03 ± 0.71 | 6% |
| Osteogenic cells | 3.40E−03 | 3.23E−03 | 2.88E−03 | 3.10E−03 ± 0.31 | −23% |
| Spleen | 5.23E−03 | 5.34E−03 | 2.80E−03 | 4.04E−03 ± 1.76 | 18% |
| Testes | 0.00E+00 | 0.00E+00 | 1.38E−03 | 1.38E−03 | −3% |
| Thymus | 2.10E−03 | 2.17E−03 | 1.86E−03 | 2.00E−03 ± 0.19 | 16% |
| Thyroid | 1.74E−03 | 1.83E−03 | 1.57E−03 | 1.68E−03 ± 0.15 | 7% |
| Urinary bladder wall | 3.12E−02 | 2.34E−02 | 1.61E−02 | 21.70E−02 ± 7.92 | −7% |
| Uterus | 4.56E−03 | 3.88E−03 | 0.00E+00 | 4.22E−03 ± 0.48 | 12% |
| Total body | 3.45E−03 | 3.20E−03 | 2.39E−03 | 2.86E−03 ± 0.66 | −1% |
| Effective dose coefficient (mSv/MBq) (ICRP 103) | 6.24E−03 | 5.07E−03 | 4.50E−03 | 5.08E−03 ± 0.82 | −6% |