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. 2021 Apr 23;11:8856. doi: 10.1038/s41598-021-88382-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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EphrinA5 protein expression is heterogeneous and associates with disease malignancy. (A) EphrinA5 IHC of a diagnosis-stage, treatment-naïve, primary HGSC tumor. Magnified images for different tumor areas. (B) Representative images of ephrinA5 IHC used for scoring the ovarian tumor TMAs. (C) Correlation of ephrinA5 protein expression with different epithelial OC subtypes and benign tumors ordered according to the weighted arithmetic mean of ephrinA5 score (descending order). t = tissue type, M = malignant, B = benign, * = mostly benign. Pearson chi‐square test showed highest overall ephrinA5 expression in HGSC (p = 9.00 × 10⁻⁶).