Table 2.

Linear mixed effects models that did and did not consider the interaction of time and SDC-1.

Outcome	No consideration for interaction between time and SDC-1					Interaction between time and SDC-1
	Coefficienta	95% LCL	95% UCL	P-value	q-valueb	P-value	q-valueb
TP	0.0012	− 0.0037	0.0061	0.638	0.729	0.362	0.482
ALB	0.0015	− 0.0013	0.0042	0.289	0.385	0.111	0.198
log_CK	0.0013	− 0.0017	0.0043	0.401	0.494	0.861	0.861
log_AST	0.0042	0.0018	0.0065	0.001	0.003	< 0.001	0.002
log_ALT	0.0034	0.0012	0.0057	0.003	0.009	< 0.001	0.001
log_LD	0.0012	0	0.0024	0.056	0.089	< 0.001	< 0.001
log_ALP	0.0002	− 0.0010	0.0015	0.695	0.741	0.001	0.004
log_ChE	− 0.0014	− 0.0032	0.0004	0.115	0.168	0.365	0.449
log_CRE	0.0020	0.0012	0.0028	< 0.001	< 0.001	0.009	0.021
log_BUN	0.0015	0.0002	0.0028	0.019	0.044	0.018	0.037
log_TG	0.0032	− 0.0455	0.0519	0.874	0.874	0.805	0.859
log_T-Bil	− 0.0026	− 0.0041	− 0.0011	0.001	0.003	0.004	0.01
FDP	0.1540	0.0230	0.2850	0.021	0.038	0.336	0.489
D-dimer	0.0821	0.0135	0.1507	0.019	0.051	0.152	0.243
AT III	− 0.0707	− 0.1307	− 0.0107	0.021	0.042	0.694	0.793
Volume of infusion per day	− 17.8331	− 25.2211	− 10.4450	< 0.001	< 0.001	< 0.001	< 0.001

All mixed effects models were adjusted for age and sex.

SDC-1 syndecan-1, TP total protein, ALB albumin, CK creatine kinase, AST aspartate aminotransferase, ALT alanine aminotransferase, LD lactate dehydrogenase, ALP alkaline phosphatase, ChE cholinesterase, CRE creatinine, BUN blood urea nitrogen, TG triglyceride, T-Bil total-bilirubin, FDP fibrin degradation product, AT III antithrombin III, LCL lower confidence limit, UCL upper confidence limit.

^aCoefficient indicates the increase in the mean value of an outcome when SDC-1 increases by 10.

^bThe q-value was calculated using the Benjamini–Hochberg method.