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. 2021 Apr 23;11:8863. doi: 10.1038/s41598-021-88346-w

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of ulipristal or/and metformin on ERα and PR expression of rats’ uteri. (A–D) photomicrographs of uteri show expression of ERα. (A) Uterine wall in the control group. (B) Uterine wall in ulipristal treated group. (C) Uterine wall in metformin treated group. (D) Uterine wall in the ulipristal and metformin treated group. × 400 magnification (scale bar = 20 μm). (E) Expression quantification of the optical density reactivity of positive cells of ERα by the ImageJ analysis system. (F–I) photomicrographs of uteri shows expression of PR. (F) Uterine wall in the control group. (G) Uterine wall in ulipristal treated group. (H) Uterine wall in metformin treated group. (I) Uterine wall in ulipristal and metformin treated group. × 400 magnification (scale bar = 20 μm). (J) Expression quantification of the optical density reactivity of positive cells of PR by the ImageJ analysis system. Data in figures (E) and (J) is represented by mean ± SD (n = 7). a or b, Statistically significant from the control or ulipristal and metformin treated group respectively at P < 0.05 using one-way ANOVA followed by Tukey as a post hoc test. UPA ulipristal, MET metformin, UPA + MET co-treatment with ulipristal and metformin.