Fig. 1. Tumor development in mice with individual and combined ablations of Brca1, Palb2, Brca2, and Trp53.

a Tumor-free survival curves of model mice with indicated genotypes. Mammary tumors are denoted by filled cycles. b Summary of tumor types and the numbers of mice of different genotypes affected by each tumor type. Note that some mice developed multiple tumors of either the same or different types. c Tumor spectra of mice with different genotypes. d Representative micrographs of H&E-stained tissue sections of mammary tumors from mice with indicated genotypes. IDC NST invasive ductal carcinoma of no special type.