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. 2021 Apr 23;7:45. doi: 10.1038/s41523-021-00253-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Genomic status of Brca1, Palb2, Brca2, and Trp53 loci in representative mammary tumors of indicated genotypes. Images were generated with an integrated genome viewer (IGV). b Genome-wide copy number plots of representative mammary tumors of indicated genotypes. Copy number of Met (c), number of somatic mutations (d), and mutation signatures (e) of mammary tumors of indicated genotypes. Mutational signature decomposition was performed using DeconstructSigs. Ageing-related signatures 1 and 5, the HRD-related signature 3, and signature 18 (SBS18) were most commonly found. Other, all other mutational signatures.