Fig. 8.

Cartilage regeneration of the optimized PRP + CPC constructs after 12 weeks in vivo. (A) Schematic diagram of the in vivo procedure and the following assessment strategy. (B) Macroscopic observation of cartilage defect healing in the 6 groups post 12-week implantation. Scale bars = 2 mm. (C, D) Histological analyses of regenerated tissue in the 6 groups at 12 weeks post-implantation. Scale bars = 1 mm. (E, F) Macroscopic and histological quantitative assessments at 12 weeks after the operation, scored according to the International Cartilage Repair Society (ICRS). Data are presented as mean ± SEM, n = 5, *P < 0.05, **P < 0.01 and ^#P > 0.05.