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. 2021 Mar 13;48:101211. doi: 10.1016/j.molmet.2021.101211

Figure 5.

Figure 5

Effect of SF1 neuron Bbs1 gene deletion on markers of thermogenesis and fat metabolism. (A) Expression level of BAT UCP1 protein (representative Western blots and quantification data are shown). (B) Baseline brown adipose tissue (BAT) sympathetic nerve activity (SNA; representative neurograms and quantification data are shown). (C–D) BAT SNA response to cooling (C, n = 15 for SF1cre/Bbs1fl/fl mice and 16 for controls [CTL]) and 2 μg leptin ICV (D, n = 6 each). (E) Baseline WAT SNA. (F) Expression levels of FAS, ATGL, HSL, and phospho-HSL in WAT (representative Western blots and quantification data are shown, n = 5–6 SF1cre/Bbs1fl/fl mice and 5–6 for CTL). ∗P < 0.05 vs. CTL group.