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. 2021 Mar 13;48:101211. doi: 10.1016/j.molmet.2021.101211

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Effect of SF1 neuron Bbs1 gene deletion on autonomic and cardiovascular functions. (A–C) Baseline splanchnic (A), lumbar (B), and renal (C) sympathetic nerve activity (SNA). (D–G) Hourly mean arterial pressure (MAP, D) and heart rate (HR, E). (n = 7 controls [CTL, 3 males and 4 females] and 9 SF1^Cre/Bbs1^fl/fl mice [4 males and 5 females]; data analyzed with 2-way ANOVA with repeated measure) (F) Baroreflex sensitivity determined by the response of renal SNA to changes in arterial pressure evoked by sodium nitroprusside and phenylephrine. (n = 6 CTL [3 males and 3 females] and 5 SF1^Cre/Bbs1^fl/fl mice [4 males and 1 female]; data analyzed with 2-way ANOVA with repeated measure). ∗P < 0.05 vs. CTL group.