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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2020 Dec 11;200:173077. doi: 10.1016/j.pbb.2020.173077

Figure 6:

Figure 6:

Pain related behaviors during spontaneous fentanyl withdrawal. (A) Mice show increased heat sensitivity using the hotplate test, whereas rats exhibit no change using the Hargreaves test. (B) Mice have increased cold sensitivity during spontaneous fentanyl withdrawal. (C) Mice and rats show no change in mechanical sensitivity. Individual points represent data from a single animal, and horizontal lines depict medians and 95% confidence intervals. Normalized data are expressed as a percent of baseline.