Table 1:

Baseline Behaviors. Raw data values at baseline. Values shown are median with 95% CI, followed by minimum, maximum, standard deviation, and sample size. Note that we assessed baseline behavior prior to any drug exposure, so sample sizes represent animals from eventual saline and fentanyl groups.

Test	Value	Mice	Rats
Withdrawal Scores	Median ± 95% CI	4, 1–5	2, 0–5
	Min	0	0
	Max	22	9
	SD	4.7	2.7
	n	27	14
Mechanical (score for mice, grams for rats)	Median ± 95% CI	1.0, 1.0–1.0	37.5, 29.9–45.1
	Min	1	12.3
	Max	1.3	134.9
	SD	0.09	28.9
	n	37	25
Heat (hotplate or Hargreaves, seconds)	Median ± 95% CI	102.5, 96.3-107.1	4.1, 3.4–5.0
	Min	72.4	2.2
	Max	122	6.5
	SD	12.2	1.1
	n	37	21
Cold	Median ± 95% CI	1.0, 1.0–1.3	n/a, did not respond
	Min	1.0	n/a
	Max	1.67	n/a
	SD	0.25	n/a
	n	37	16
Grimace	Median ± 95% CI	0.28, 0.17-0.35	0.5, 0.35–0.68
	Min	0	0.09
	Max	0.88	1.1
	SD	0.17	0.27
	n	27	29