Table 6.
Associations between gender, monthly standard drinks and brain volumes that demonstrated significant group-by-gender interactions in people with alcohol dependence
| Mixed-effect model adjusted for age, education and ICV | Alcohol-dependent (n = 484, 36% women) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| R Amygdala | L Amygdala | R Cerebellum GM | L cerebellum GM | ||||||
| β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | ||
| Model A | Gendera | 47.78 (0.28, 95.28) | 0.049* | 58.19 (9.92, 106.45) | 0.018* | -1255.93 (-2455.24, -56.62) | 0.040 | -1453.91 (-2648.76, -259.06) | 0.017* |
| StDr/mo | -7.66(-11.79,-3.52) | <0.001** | -7.139(-11.33,-2.95) | 0.001** | 89.84 (-14.52, 194.20) | 0.092 | 82.34 (-21.63, 186.32) | 0.121 | |
| Model B | Gender-by-StDr/mo | 0.84 (-6.78, 8.47) | 0.829 | -1.06 (-8.88, 6.75) | 0.790 | -267.73(-458.04,-77.43) | 0.006** | -262.53(-452.18,-72.89) | 0.007** |
| Model C (men only) |
StDr/mo | -8.92(-13.67,-4.17) | <0.001** | -8.66(-13.61,-3.71) | 0.001** | 70.80 (-53.69, 195.29) | 0.265 | 69.62 (-55.88, 195.12) | 0.277 |
| Model D (women only) |
StDr/mo | -7.28 (-15.40, 0.85) | 0.079 | -8.01 (-15.63, -0.39) | 0.039 | 148.6 (-36.38, 333.58) | 0.115 | 20.05 (-142.87, 182.97) | 0.809 |
Note: three separate models were run to explore the association between ROIs volume and gender, standard drinks (model A), gender-by-standard drinks (model B) or standard drinks separately in men and women (model C, D). Only the right amygdala and the right cerebellum GM demonstrated significant group-by-gender interactions after FDR correction however, both the right and the left hemisphere of these regions are presented as the coefficient of their interaction effects was very similar (see table 2). β = beta, CI = confidence interval, GM = grey matter, L = left, R = right, StDr/mo = monthly standard drinks. a Me(FDR-corrected).
Bolded values are β (95% CI), p and d of the significant effects (FDR-corrected). * p(uncorrected) < 0.05; ** p(FDR) < 0.05.