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. 2021 Apr 1;11(4):643. doi: 10.3390/diagnostics11040643

Figure 1.

Figure 1

(A) Overview of the glycosyltransferases that are upregulated in cancer. GnT-IV, N-acetylglucosaminyltransferase IV; GnT-V, N-acetylglucosaminyltransferase IV; ST3Gal I, β-galactoside alpha-2,3-sialyltransferase 1; ST6Gal I, β-galactoside alpha-2,6-sialyltransferase 1; FucT, α1-3-fucosyltransferase. (B) N-Glycan structures that are of relevance in glycan biomarker studies on OvCa. At the level of total serum, high-mannose and biantennary bisecting N-glycans are downregulated, whereas sialylated fucosylated tri- and tetraantennary N-glycans are upregulated when primary OvCa patients as compared with controls. Besides, elevated bisecting N-glycans and some sialylated fucosylated tetraantennary structures have also been proposed as a marker for resistance to chemotherapy. Green circle, mannose; yellow circle, galactose; blue square, N-acetylglucosamine; red triangle, fucose; purple diamond, N-acetylneuraminic acid.