Table 5.

Saturation solubility of KT in different excipients (surfactants, cosurfactants, oils, deionized water, and simulated tear fluid).

Excipients	Solubility 1 (mg/mL)	Excipients	Solubility 1 (mg/mL)
Tween 20	7.30 ± 0.20	Pentylene glycol	16.04 ± 0.95
Tween 60	9.89 ± 0.17	Hexylene glycol	10.36 ± 0.85
Tween 80	3.82 ± 0.41	Dimethyl isosorbide	4.54 ± 0.55
Span 20	5.01 ± 0.27	2-butyl-2-ethyl-1,3-propandiol	9.55 ± 0.60
Span 80	3.18 ± 0.37	2,3-butanediol	22.93 ± 0.24
Cremophor RH 40	9.00 ± 0.21	Transcutol P	13.32 ± 0.11
Cremophor EL	4.03 ± 0.38	Triacetin	0.06 ± 0.001
Labrasol ALF	6.64 ± 0.13	Ethyl Oleate	0.04 ± 0.01
Labrafil M2125 CS	0.48 ± 0.06	Labrafac PG	0.01 ± 0.002
Labrafil M1944 CS	0.33 ± 0.03	Labrafac lipophile WL 1349	0.01 ± 0.01
Labrafil M2130 CS	0.80 ± 0.04	Isopropyl Myristate	0.01 ±0.02
Ethylene glycol	36.84 ± 0.40	Simulated tear fluid	199.2 ± 7.40
Propylene glycol	26.23 ± 0.82	Deionized water	217.1 ± 1.13
Butylene glycol	21.09 ± 1.22

¹ Mean ± SD, n = 3.