Table 6.
Ocular irritation potential calculated from the cumulative scores of the vascular responses of the CAM.
| Surfactants, Cosurfactants & Oils | Irritation Potential (Numerical Score) |
|||
|---|---|---|---|---|
| Practically Non (0.0–0.9) |
Slight (1.0–4.9) |
Moderate (5.0–8.9) |
Strong (9.0–21.0) |
|
| KT solution | √ | |||
| Tween 20 | √ | |||
| Tween 60 | √ | |||
| Tween 80 | √ | |||
| Span 20 | √ | |||
| Span 80 | √ | |||
| Cremophor RH 40 | √ | |||
| Cremophor EL | √ | |||
| Labrasol ALF | √ | |||
| Labrafil M2125 CS | √ | |||
| Labrafil M1944 CS | √ | |||
| Labrafil M2130 CS | √ | |||
| Ethylene glycol | √ | |||
| Propylene glycol | √ | |||
| Butylene glycol | √ | |||
| Pentylene glycol | √ | |||
| Hexylene glycol | √ | |||
| Dimethyl isosorbide | √ | |||
| 2-Butyl-2-ethyl-1,3-propandiol | √ | |||
| 2,3-Butanediol | √ | |||
| Transcutol P | √ | |||
| Triacetin | √ | |||
| Ethyl Oleate | √ | |||
| Labrafac PG | √ | |||
| Labrafac lipophile WL 1349 | √ | |||
| Isopropyl Myristate | √ | |||
| Normal saline | √ | |||
| NaOH (0.1 M) | √ | |||