Figure 4.

Effect of cordycepin in vivo. (A) Survival of silkworm larvae injected with 100 μL of 12.5 mM cordycepin or 2′-deoxyadnosine (n = 5, triplicate). COR and 2′-dADE indicate cordycepin and 2′-deoxyadenosine. Results are significantly different using the log-rank test (p < 0.0001, χ² = 16.99). (B) Appearance of larvae at three days after injection with of cordycepin or 2′-deoxyadnosine. (C) Survival of larvae injected with 50 μL of 12.5 mM cordycepin or 2′-deoxyadnosine and 25 μL of 1 × 10⁶ conidia/mL of C. militaris NBRC103752 conidia (n = 5 or 10, triplicate). COR and 2′-dADE indicate cordycepin and 2′-deoxyadenosine. Survival rates for cordycepin and 2′-deoxyadnosine were significantly different using the log-rank test (p < 0.0001, χ² = 83.08).