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. 2021 Mar 25;11(4):593. doi: 10.3390/diagnostics11040593

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Diasorin cut-off for titer 80. (b) Beckman Coulter cut-off for titer 80. (c) Euroimmun cut-off for titer 80. Legend: ROC curve for Diasorin, Beckman Coulter and Euroimmun, titer <80 vs. ≥80 where the ROC curve is labeled by all possible cut-offs. These ROC curves are atypical, and, above all, their vertical parts increase at the point of 100% specificity, demonstrating that it was not targeted at 100% specificity, but 95%. For some methodologies, however, it accidentally led to 100% specificity. For cut-off values for individual methods, see Table 4.

(a) Diasorin cut-off for titer 80. (b) Beckman Coulter cut-off for titer 80. (c) Euroimmun cut-off for titer 80. Legend: ROC curve for Diasorin, Beckman Coulter and Euroimmun, titer <80 vs. ≥80 where the ROC curve is labeled by all possible cut-offs. These ROC curves are atypical, and, above all, their vertical parts increase at the point of 100% specificity, demonstrating that it was not targeted at 100% specificity, but 95%. For some methodologies, however, it accidentally led to 100% specificity. For cut-off values for individual methods, see Table 4.