Table 2.
The impact of classified tumor-suppressive miRs on carcinogenic the signature through the specific target.
| miRNA | Disease | Manipulating Mechanism | Candidate | Physiological Influence | Reference |
|---|---|---|---|---|---|
| miR-1 | CRC | Epigenetic control; miRNA sponge | VEGF, NOTCH3 | Proliferation, migration, motility and metabolism | [25,26,27] |
| miR-133 | CRC | Epigenetic control; miRNA sponge | FSCN1, SENP1 | Growth or motility of CRC cells | [28] |
| miR-206 | CRC, LC | Epigenetic control; miRNA sponge | FMNL2, NOTCH3, BCL2, STA3, HIF-1, Coronin 1C | Migration, proliferation, and immortality, metastasis | [29,65,76] |
| miR15/16 | CRC | Transcriptional control (SIRT1) | cyclin B1, TFAP-4, Bcl-2,K-Ras, MYB | Epithelial mesenchymal transition (EMT), apoptosis | [35,36,37,38] |
| let-7 family | CRC; Cervical cancer | miRNA sponge | PHD, ring finger domains 2, RTKN, IGF-1, MYC, MMP11, PBX3, DCLK1, STAT3 | Cell cycle arrest, metastasis | [43,44,45,46,47,145,146] |
| miR-125 | CRC Cervical Cancer | miRNA sponge | Bcl-2, Mcl-1, SMURF1, VEGFA, CREB5, STAT3, MMP-9, MMP-2, N-cadherin | Apoptosis, angiogenic or metastatic activity, inflammaation | [50,51,52,146] |
| let-7 family | LC | miRNA sponge | Ras | Proliferation | [57] |
| miR-126 | LC | miRNA sponge | PTEN, CX3CR1 | Proliferation, metastasis | [58,73] |
| miR-34 | LC; Cervical Cancer | Transcriptional control (p53) | Cyclin E2, HMGB1 | Cell cycle arrest | [59,141] |
| miR-128 | LC | miRNA sponge | VEGFA, VEGFR2, VEGFR3 | Angiogenesis | [64] |
| miR-135a | LC | miRNA sponge | IGF-1 | Angiogenesis | [66] |
| miR-192 | LC | Transcriptional control (p53) | TRIM44 | Metastasis | [74] |
| miR-7 | LC; Ovarian cancer | miRNA sponge | Nova2, EGFR | Angiogenesis, EMT | [75,137] |
| miR-335 | LC | miRNA sponge | ROCK1 | EMT | [77] |
| miR-98 | LC | miRNA sponge | TGFβR1 | Proliferation, migration, and invasion | [78] |
| miR-199 | BC | Transcriptional control (hedgehog signaling) | Ezh2, β-catenin, Ki-67 | Proliferation, migration, and invasion | [93,94,95] |
| miR-214 | BC | Transcriptional control (hedgehog signaling) | Ezh2, β-catenin, Ki-67 | Proliferation, migration, and invasion | [93,94,95] |
| miR-29 | HCC | Transcriptional control (NF-κB, TGF-β) | CDC42, PIK3R1, Bcl-2, Mcl-1 | Cell cycle, apoptosis | [112] |
| miR-101 | HCC; Cervical Cancer | miRNA sponge | Mcl-1, Cox-2 | Apoptosis, inflammation, proliferation, invasion | [115,140] |
| miR-125b | HCC | Epigenetic, transcriptional control; miRNA sponge | Mcl-1 | Apoptosis | [115] |
| miR-122 | HCC | Transcriptional control (C/EBP, HNF) | Cyclin G1, PKM2, and Wnt family member 1 | Cell cycle, apoptosis | [108] |
| miR-150 | Ovarian cancer | miRNA sponge | ZEB1 | Invasion, metastasis | [134,135] |
| miR-22, miR-183, miR-31 | Ovarian cancer | Transcriptional control (Snail) | TIAM1 | Invasion, migration | [136] |
| miR-429 | Cervical Cancer | miRNA sponge | IL-6,IFN-β | Chronic inflammation | [139] |
| miR-142 | Cervical Cancer | miRNA sponge | HMGB1 | Chronic inflammation, progressive tumorigenesis, active metastasis | [141,142,143] |
| miR-24 | Cervical Cancer | Uncertain | chitinase-3-like protein 1 | Proliferation, metastasis, inflammation | [144] |
| miR-451 | Cervical Cancer | Uncertain | IL-6 receptor | Inflammation, invasion, angiogenesis, proliferation | [144] |