Table 3.
Summary of changes in bone outcomes.
| TRE (n = 11) | Non-TRE (n = 9) | p-Values | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Bone Outcome | Pre- Intervention |
Post- Intervention |
Change | Pre- Intervention |
Post- Intervention |
Change | Treatment | Time | Treatment × Time |
| Total body BMC, g | 2852 ± 173 | 2866 ± 162 | 13.5 ± 8.6 | 2801 ± 159 | 2784 ± 159 | −17.8 ± 7.9 | 0.80 | 0.83 | 0.02 |
| Total body BMD, g/cm2 | 1.33 ± 0.04 | 1.33 ± 0.04 | 0.002 ± 0.01 | 1.25 ± 0.03 | 1.25 ± 0.03 | 0.001 ± 0.05 | 0.13 | 0.82 | 0.94 |
| T-score, SD | 2.2 ± 0.3 | 2.2 ± 0.3 | 0.02 ± 0.04 | 1.5 ± 0.3 | 1.5 ± 0.3 | 0.01 ± 0.04 | 0.08 | 0.56 | 0.73 |
| Z-score, SD | 1.6 ± 0.3 | 1.8 ± 0.4 | 0.14 ± 0.1 | 0.6 ± 0.3 | 0.7 ± 0.3 | 0.06 ± 0.06 | 0.61 | 0.10 | 0.95 |
| P1NP, ng/mL 1 | 18.7 ± 1.3 | 18.5 ± 1.5 | −0.22 ± 0.9 | 28.8 ± 8.8 | 24.7 ± 8.2 | −4.07 ± 1.4 | 0.57 | 0.04 | 0.07 |
| NTX, pg/mL 1 | 1074 ± 112 | 1102 ± 104 | 28.3 ± 68 | 1780 ± 513 | 1722 ± 327 | −57.9 ± 237 | 0.13 | 0.30 | 0.83 |
| PTH, pg/mL 1 | 45.0 ± 6.9 | 52.3 ± 5.6 | 7.3 ± 3.3 | 62.8 ± 8.2 | 75.2 ± 10.1 | 12.3 ± 13.5 | 0.09 | 0.10 | 0.64 |
Values represent mean ± SEM unless otherwise indicated. p-values are based on the results of the general linear mixed model analyses. BMI, body mass index; BMC, bone mineral content; BMD, bone mineral density; P1NP, procollagen 1 N-terminal propeptide; NTX, cross-linked N-telopeptide of type I collagen; PTH, parathyroid hormone. 1 Analyses based on n = 9 participants from the TRE group who had pre- and post-intervention blood samples.