Figure 1.

Pressure overload-induced heart failure is ameliorated by RAPA treatment. (A) Heart weight to tibia length (HW/TL). (B) Echocardiographic-assessed left ventricular mass matched to tibia length (LVM/TL). (C) Gradient P determining degree of aortic banding. (D) Echocardiographic-assessed diastolic left ventricular internal diameter (LVID-d). (E) Ejection fraction (EF). (F) Relative gene expression of atrial natriuretic peptide (ANP). Data are revealed 10 weeks post-surgery and presented as Mean + SEM of biological replicates. Statistical analyses were performed by either two-way-ANOVA followed by Bonferroni posttest or unpaired t- test (indicated with #). Significant differences are shown by p < 0.05, * vs. SHAM VEH, † vs. TAC VEH, ‡ vs. SHAM RAPA.