Table 7.

Association of representative SNPs for each LD-group with glucose and lipid metabolism, and liver parameters in the Sorbs cohort.

		LD 1	LD 2	LD 3	LD 4	LD 5	LD 6	LD 7	LD 8	n
Fasting glucose	β	−0.018	0.005	−0.003	0.003	0.004	0.016	0.012	0.002
	s.e.	0.013	0.008	0.010	0.008	0.008	0.016	0.015	0.009	946
	p	0.183	0.486	0.777	0.746	0.624	0.315	0.424	0.857
Fasting insulin	β	0.128	0.030	0.049	0.018	0.030	0.111	0.044	0.026
	s.e.	0.042	0.025	0.030	0.025	0.027	0.052	0.046	0.029	946
	p	0.002	0.214	0.104	0.468	0.269	0.033	0.349	0.371
HOMA-IR	β	0.109	0.047	0.044	0.030	0.036	0.135	0.066	0.046
	s.e.	0.046	0.027	0.033	0.0274	0.029	0.056	0.051	0.032	935
	p	0.019	0.079	0.180	0.274	0.215	0.017	0.196	0.155
HbA1c	β	−0.005	0.001	0.001	0.001	0.001	0.002	0.001	0.008
	s.e.	0.007	0.004	0.005	0.004	0.004	0.009	0.008	0.005	953
	p	0.472	0.884	0.834	0.819	0.804	0.845	0.859	0.086
LDL-C	β	−0.031	−0.034	−0.021	−0.044	−0.032	0.016	0.021	−0.041
	s.e.	0.022	0.012	0.015	0.012	0.013	0.025	0.023	0.015	845
	P	0.150	0.005	0.165	4.482 × 10−4	0.018	0.538	0.352	0.005
HDL-C	β	0.010	−0.006	−0.001	−0.017	−0.016	−0.028	0.021	0.010
	s.e.	0.017	0.010	0.012	0.010	0.011	0.021	0.019	0.012	845
	p	0.578	0.511	0.962	0.100	0.129	0.178	0.263	0.417
TG	β	0.043	−0.031	0.017	−0.030	−0.018	0.072	0.008	−0.012
	s.e.	0.038	0.021	0.026	0.022	0.023	0.045	0.040	0.026	845
	p	0.260	0.142	0.517	0.169	0.427	0.107	0.833	0.642
γGT	β	0.052	-0.035	−0.027	−0.001	−0.007	0.072	−0.113	−0.043
	s.e.	0.048	0.028	0.035	0.029	0.030	0.059	0.053	0.034	958
	p	0.287	0.205	0.429	0.965	0.828	0.224	0.034	0.198
AP	β	0.014	0.022	0.009	0.020	0.014	0.020	0.003	0.018
	s.e.	0.021	0.012	0.015	0.012	0.013	0.026	0.023	0.015	958
	p	0.521	0.077	0.530	0.115	0.304	0.439	0.912	0.210
ALAT	β	0.006	−0.026	−0.017	−0.025	−0.023	0.015	−0.012	−0.014
	s.e.	0.030	0.017	0.021	0.017	0.019	0.036	0.033	0.021	958
	p	0.850	0.133	0.425	0.145	0.217	0.685	0.724	0.508
ASAT	β	0.020	−0.020	−0.006	−0.022	−0.013	0.007	−0.003	−0.016
	s.e.	0.019	0.011	0.013	0.011	0.012	0.023	0.021	0.013	958
	p	0.281	0.068	0.661	0.047	0.263	0.754	0.865	0.231

The presented associations were given for the representative SNP within each LD-group. Prior to analysis, all variables were ln-transformed except the covariate sex. p-values were adjusted for: sex, age, BMI and a p-value 0.05 was considered to be significant and was highlighted in bold. Linear regression including all subjects was conducted. For lipid parameters only subjects without lipid lowering medication were analyzed. LD = linkage disequilibrium; HOMA-IR = homeostasis assessment model of insulin resistance; HbA1c = hemoglobin A1c; LDL-C = low density lipoprotein cholesterol; HDL-C = high density lipoprotein cholesterol; TG = triglyceride; γGT = gamma-glutamyltransferase; AP = alkaline phosphatase; ALAT = alanine aminotransferase; ASAT = aspartate aminotransferase; BMI = body-mass index; p = p-value; β = regression coefficient; s.e. = standard error; n = number of subjects.