Table 8.

Association of representative SNPs for each LD-group with FGF21-parameters and anthropometric parameters in the Sorbs cohort.

		LD 1	LD 2	LD 3	LD 4	LD 5	LD 6	LD 7	LD 8	n
FGF21- serum level	β	0.227	0.068	0.048	0.081	0.076	−0.155	0.001	0.079
	s.e.	0.088	0.051	0.063	0.052	0.056	0.108	0.098	0.061	724
	p	0.010	0.180	0.453	0.121	0.173	0.150	0.989	0.195
FGF21- expression	β	−0.001	1.261 × 10−4	2.669 × 10−4	−0.001	−0.001	−2.052 × 10−4	0.003	0.001
	s.e.	0.002	0.001	0.001	0.001	0.001	0.002	0.002	0.001	938
	p	0.424	0.900	0.830	0.313	0.357	0.923	0.165	0.571
BMI	β	−0.010	−0.006	−0.007	−0.005	−0.005	0.004	−0.002	−0.001
	s.e.	0.012	0.007	0.008	0.007	0.007	0.014	0.013	0.008	958
	p	0.430	0.358	0.390	0.517	0.523	0.785	0.901	0.940
WHR	β	0.005	3.225 × 10−4	0.004	0.001	0.002	4.664 × 10−4	4.915 × 10−4	0.003
	s.e.	0.005	0.003	0.004	0.003	0.003	0.006	0.006	0.003	957
	p	0.283	0.912	0.315	0.724	0.622	0.940	0.929	0.403
Height	β	−0.002	−0.002	−0.004	0.001	0.001	0.004	−0.009	−0.003
	s.e.	0.003	0.002	0.002	0.002	0.002	0.003	0.003	0.002	958
	p	0.515	0.276	0.031	0.726	0.418	0.228	0.003	0.069
Weight	β	−0.005	−0.004	−0.009	8.199 × 10−5	0.002	0.008	−0.018	−0.007
	s.e	0.005	0.003	0.004	0.003	0.003	0.007	0.006	0.004	958
	p	0.323	0.160	0.022	0.980	0.647	0.226	0.003	0.051
SBP	β	−0.002	−0.002	−0.008	−0.057	0.004	0.020	−0.009	−4.078 × 10−4
	s.e.	0.008	0.005	0.006	0.005	0.005	0.010	0.009	0.006	958
	p	0.850	0.659	0.193	0.991	0.475	0.054	0.322	0.944

The presented associations were given for the representative SNP within each LD-group. Prior analysis, all variables were ln-transformed except the covariate sex. p-values were adjusted for: sex, age, BMI and p-values 0.05 were considered to be significant and highlighted in bold. Association analysis was done using linear regression analysis. LD = linkage disequilibrium; FGF = fibroblast growth factor; BMI = body-mass index; WHR = waist-to-hip ratio; SBP = systolic blood pressure; p = p-value; β = regression coefficient; s.e. = standard error; n = number of subjects.