Table 9.

Association of representative SNPs for each LD-group with adipokines in the Sorbs cohort.

		LD 1	LD 2	LD 3	LD 4	LD 5	LD 6	LD 7	LD 8	n
IGF-1	β	−0.014	−0.017	0.001	−0.029	−0.028	0.020	0.038	0.004
	s.e.	0.023	0.013	0.017	0.014	0.015	0.029	0.026	0.016	958
	p	0.562	0.208	0.955	0.034	0.057	0.491	0.144	0.783
Chemerin	β	−0.001	−0.014	−0.017	−0.014	−0.015	0.010	−0.017	−0.021
	s.e.	0.024	0.014	0.017	0.014	0.015	0.030	0.027	0.017	929
	p	0.961	0.306	0.312	0.337	0.332	0.748	0.528	0.203
Progranulin	β	0.027	0.007	0.013	0.008	0.007	0.019	0.005	0.006
	s.e.	0.019	0.011	0.014	0.011	0.012	0.023	0.021	0.013	957
	p	0.156	0.513	0.336	0.472	0.541	0.424	0.801	0.668
AFABP	β	0.088	0.027	0.026	0.019	0.013	0.020	0.010	0.029
	s.e.	0.040	0.023	0.029	0.024	0.025	0.050	0.045	0.028	930
	p	0.028	0.245	0.364	0.416	0.612	0.690	0.827	0.296
Adiponectin	β	0.057	−0.011	0.014	−0.014	−0.008	0.014	0.008	−0.004
	s.e.	0.026	0.015	0.019	0.015	0.016	0.032	0.029	0.018	928
	p	0.031	0.482	0.458	0.343	0.637	0.660	0.786	0.807
Irisin	β	−0.001	−0.002	−0.017	0.002	−0.008	0.002	−0.023	−0.004
	s.e.	0.025	0.014	0.018	0.015	0.016	0.031	0.027	0.017	954
	p	0.984	0.878	0.336	0.869	0.624	0.939	0.401	0.810
Vaspin	β	0.046	−0.030	0.031	−0.044	−0.030	0.129	0.036	0.029
	s.e.	0.078	0.045	0.055	0.046	0.049	0.095	0.085	0.054	952
	p	0.562	0.500	0.577	0.333	0.536	0.173	0.674	0.586
AGF	β	0.053	0.065	−0,058	0.066	0.021	0.154	0.055	−0.008
	s.e.	0.101	0.057	0.072	0.059	0.063	0.125	0.110	0.069	768
	p	0.600	0.256	0.999	0.263	0.737	0.218	0.616	0.904
pro-NT	β	−0.030	−0.005	−0.044	−0.003	−0.011	−0.030	−0.023	−0.016
	s.e.	0.031	0.018	0.022	0.018	0.019	0.037	0.034	0.021	953
	p	0.323	0.758	0.045	0.869	0.562	0.438	0.495	0.449
PENK	β	0.015	0.001	0.003	−0.006	0.004	0.066	0.029	0.014
	s.e.	0.021	0.012	0.015	0.012	0.013	0.025	0.023	0.014	953
	p	0.480	0.958	0.827	0.604	0.770	0.009	0.195	0.336

The presented associations are given for the representative SNP within each LD-group. Prior to analysis, all variables were ln-transformed except the covariate sex. p-values were adjusted for: sex, age, BMI and a p-value 0.05 was considered to be significant and highlighted in bold. Linear regression including all subjects was conducted. LD = linkage disequilibrium; IGF-1 = insulin like growth factor 1; AFABP = adipocyte fatty acid-binding protein; AGF = angiopoietin-related growth factor; pro-NT = pro-neurotensin; PENK = pro-enkephalin; BMI = body-mass index; p = p-value; β = regression coefficient; s.e. = standard error; n = number of subjects.