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. 2021 Mar 28;12(4):493. doi: 10.3390/genes12040493

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ascaris genome, programmed DNA elimination, and chromosome evolution. Germline chromosomes are illustrated with the length of the chromosome in Mb on the right. Chromosome regions that are eliminated are colored in red. The retained regions, which will become somatic chromosomes after DNA elimination, are colored based on their corresponding C. elegans chromosomes (see legends). CENP-A deposition (data from 12 developmental stages [37]) are illustrated by green dots underneath the chromosomes, illustrating possible centromeric regions for the holocentric chromosomes; shown are the top 2000 (out of 3342) CENP-A enriched sites.