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. 2021 Mar 27;12(4):488. doi: 10.3390/genes12040488

Table 1.

Ion and voltage-gated channels of mammalian sperm.

Location Specie
Human Bovine Dog Mouse Rat
Head Cav2.1c, Cav3.1d, Cav3.3d, TRPC1a, TRPC3a, TRPC4a, TRPC6a, IP3R j IP3R j IP3R j Cav1.2b, Cav2.1c, Cav2.2d, Cav2.3d, Cav3.1d, Cav3.2d, TRPC2a, IP3R j IP3R j
Mid-piece Cav1.2b, Cav2.3d, Cav3.1d, Cav3.2d, Cav3.3d, TRPC3a, TRPC4a, TRPC6a CNGA3e Catsper2h, Cav2.1c, Cav2.3d, Cav3.1d, Cav3.3d, TRPC1a, TRPC3a, TRPC6a
Upper tail Cav1.2b, Cav3.1d, Cav3.2d, TRPC1a, TRPC4a, TRPC6a CNGA3e, CNGB1f Catsper1g, Catsper2h,
Cav1.2b, Cav2.2d, Cav2.3d, Cav3.1k, Cav3.2d, Cav3.3d, TRPC1a, TRPC3a
Lower tail Cav2.3d CNGA3e Cav3.2d, TRPC3a

Note: TRPC, transient receptor potential channel; Cav, voltage-gated calcium channels; Catsper, cation channel of sperm; IP3R, inositol tri-phosphate receptor; CNG, cyclic nucleotide gated (Channels). a [58,59,60,61]; b [62]; c [63]; d [64,65,66]; e [67,68]; f [69]; g [70]; h [71]; j [72]; k [73].