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. 2021 Mar 30;9(4):358. doi: 10.3390/biomedicines9040358

Table 4.

Pharmacokinetic parameters at the dose 25 mg/kg of caffeic acid (CA) orally administered in UUO mice. AUC represents the calculated area under the curve between 0 and 360 min. Cmax is the maximum concentration achieved. tmax is the required time to achieve Cmax. Bioavailability (F) is the fraction of the administered dose that is available to the systemic circulation. Values are means; n = 3 animals/time.

Parameter Oral Administration (Gavage)
Caffeic Acid
AUC (0–360) 4964
Cmax (μM) 50.5
tmax (min) 30
F (%) 0.4