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. 2021 Mar 31;13(4):597. doi: 10.3390/v13040597

Figure 1.

Figure 1

Models for capsid docking at the nuclear pore. Proper docking orientation of the capsid with the portal vertex facing the nuclear pore enables ejection of the viral DNA to the nucleus through the portal, across the nuclear pore complex (NPC). Nuclear docking is mediated by the capsid vertex-specific component (CVSC; also termed capsid-associated tegument complex (CATC)) (A). Theoretical model for improper docking orientation, with one of the 11 penton vertices facing the nuclear pore, prevents DNA release and, thus, leads to a ‘dead-end’ infection (B). Nucleoporins (Nups) 358, 214, and 153, Phenylalanine-Glycine (FG) filaments.