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Glucuronidation potency of the compounds C-2028, C-2045 and C-2053 (0.05 mM) with UGT1 and UGT2 families of human recombinant UDP-glucuronosyltransferases (1 mg/mL UGT and 5 mM UDPGA cofactor), Symbols “−“ and “+” means the lack of UGT activity and the significant UGT activity, respectively
| UGT 1A1 |
UGT 1A6 |
UGT 1A9 |
UGT 1A10 |
UGT 2B4 |
UGT 2B7 |
UGT 2B15 |
UGT 2B17 |
|
|---|---|---|---|---|---|---|---|---|
| C-2028 | − | − | − | − | − | − | − | − |
| C-2045 | + | +/− | + | + | − | − | − | − |
| C-2053 | − | − | − | − | − | − | − | − |
