Table 1.
Dose Group. | Number of Mice | Dose Per Mouse | Infection | Neutral. Ab Titer | Viral Load Log10 | Alveolar Score | Blood Vessel Score | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Normal | Mild | Mod. | Normal | Mild | Mod. | ||||||
High | 10 | 5 µg | 105TCID50/50 µL | 1024 * | 0+/−0 * | 2 | 7 | 1 | 6 | 4 | 0 |
Medium | 10 | 1 µg | >1024 * | 0+/−0 * | 1 | 7 | 2 | 3 | 7 | 0 | |
Control | 8 | - | <8 | 6+/−0.22 | 0 | 2 | 6 | 3 | 5 | 0 |
* p << 0.001 compared to control. Listed from left to right are, for each dose group, number of animals per group; vaccine dose per animal per shot; viral infection dose per animal; titers of neutralizing antibodies with <8 being below the lower limit and >1024 being higher than upper limit of quantification; viral load given as log10 of the viral particle count; and the number of animals per lung lesion score (see Figure 1 for definition of scores).