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. 2021 Mar 31;12(4):513. doi: 10.3390/genes12040513

Figure 3.

Figure 3

Loxl4-KO mice did not spontaneously develop aortic aneurysm at 12 months. (A) Representative aortic images from wild-type and Loxl4-KO mice at the age of 12 months. (B) Lumen diameters of ascending aorta, aortic arch, and abdominal aorta from wild-type (n = 5) and Loxl4-KO mice (n = 5), p = 0.9356, 0.4829 and 0.0770, respectively. (C) Mouse thoracic aortas and abdominal aortas were sectioned and stained by elastic staining. Pictures were taken at a magnification of 10×. The bar is 100 µm. (D) Blood pressure in wild-type (n = 6) and Loxl4-KO mice (n = 5), p = 0.1522. (E) Serum Metalloproteinase-2 (MMP2) activity was measured from wild-type (n = 15) and Loxl4-KO mice (n = 13), p = 0.8863. (F) Relative mRNA expression of Mmp9 in whole aortas of wild-type (n = 4) and Loxl4-KO mice (n = 3), p = 0.9102. (G) The serum Mmp9 level was measured by Western blotting, and an about 100 kDa specific metalloproteinase-9 (MMP9) band was detected in wide-type and Loxl4-KO mice, p = 0.6533.