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. 2021 Mar 31;12(4):513. doi: 10.3390/genes12040513

Figure 5.

Figure 5

Loxl4 deletion did not exaggerate angiotensin II-induced thoracic aortic aneurysms (TAA) or abdominal aortic aneurysms (AAA) in mice at the age of 20 weeks. (A) Representative aortic images from wild-type and Loxl4-KO mice after angiotensin II (1.44 mg/kg/d) infusion. (B) Masson’s staining, HE staining, and elastic staining of the abdominal aortic aneurysm from wild-type and Loxl4-KO mice. Pictures were taken at a magnification of 4×. The bar is 400 µm. (C) Aortic aneurysm was detected in 6 of 21 wild-type mice and in 7 of 23 Loxl4-KO mice, p = 0.8924. (D) Blood pressure changes in angiotensin II-infused wild-type and Loxl4-KO mice. Days of measurement are indicated with respect to pump implantation. Day 0 = basal blood pressure before pump implantation. (E) Aortic pulse wave velocity (PWV) of mice received angiotensin II infusion for 4 weeks, p = 0.8734. (F) Lumen diameters of ascending aorta, aortic arch, and abdominal aorta from wild-type (n = 18) and Loxl4-KO mice (n = 13), p = 0.9842, 0.1145, and 0.3418, respectively.