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. 2021 Apr 16;31(3):214–226. doi: 10.1089/cap.2020.0148

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© Azmi Nasser et al. 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 2. — Link functions for ADHD-RS scores and CGI-S/CGI-I levels. Children (blue lines) and adolescents (red lines) are from the present analysis in pediatric patients treated with SPN-812 or placebo. Shaded bands represent 95% confidence intervals for link functions by age group, that is, collapsed across study. For clarity, some points were omitted without changing the shape of the line: included on (A) and (B) is every second point; on (C), every sixth point. (A) Baseline ADHD-RS-5 Total scores and CGI-S levels. (B) ADHD-RS-5 Total score absolute change from baseline and CGI-I levels at the end of study. (C) ADHD-RS-5 Total score percent change from baseline and CGI-I levels at the end of study. ADHD-RS-5, Attention-Deficit/Hyperactivity Disorder Rating Scale 5; CGI, Clinical Global Impressions; CGI-I, CGI-Improvement; CGI-S, CGI-Severity.