Fig. 2.

Beta weights from the elastic net regression for each ROI and modality associated with BMI at baseline. A) Cortical ROIs; B) Subcortical ROIs. The signs of the beta weights are in reference to each other and do not necessarily represent thickening or thinning. However, 64 % of the structural ROIs identified were negatively correlated with BMI indicating that BMI was associated with smaller cortical thickness, surface area, and lower FA and MD (data not shown). Subcortically, BMI was positively correlated with gray matter volumes and most subcortical FA and MD white matter estimates (data not shown). C) Absolute beta weights sorted by each ROI and modality from the baseline elastic net model. D) Summed average absolute beta weights from the elastic net regression indicate magnitude of each contributing structural modality. CT = cortical thickness; DTI = Diffusion tensor imaging; FA = fractional anisotropy; MD = mean diffusivity; vol = volume; Subcort = subcortical; Edu = parent reported highest education.