Figure 4.

Citicoline (CDP-choline) accelerated remyelination in the corpus callosum of mice 0.5 weeks after cuprizone withdrawal. Mice were fed with cuprizone for five weeks to induce demyelination. Later, cuprizone was withdrawn, and mice were allowed to remyelinate. The extent of myelination was judged by scoring of proteolipid protein (PLP) in a blinded manner by three observers and expressed in a 3-point scale from 0 (complete demyelination) to 3 (normal myelin). In (A) the box marks the area of the brain coronal section in which myelin scoring was performed, shown in (B). Statistical significance: *** p < 0.001. Reproduced from [45], by permission of Oxford University Press.